Aqua Meds NitroCure™
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 25 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 50 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 100 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 250 grams.
Aqua Meds NitroCure back label showing nitrofurazone dosage instructions and treatment directions for koi and goldfish.
Aqua Meds NitroCure™
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 25 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 50 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 100 grams.
Aqua Meds NitroCure nitrofurazone treatment for koi and goldfish bacterial infections. 250 grams.
Aqua Meds NitroCure back label showing nitrofurazone dosage instructions and treatment directions for koi and goldfish.

Aqua Meds NitroCure™

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Aqua Meds NitroCure™

NitroCure™ is Aqua Meds' 100% pure nitrofurazone treatment for koi and goldfish. It is a practical first choice for many common bacterial problems, especially when the issue is external or when you need to treat a pond, tank, or group of fish rather than chasing one fish at a time.

NitroCure™ is commonly used for ulcers, fin rot, tail rot, gill disease, and other bacterial issues where reducing bacterial pressure in the water is an important part of the treatment plan. Depending on the situation, NitroCure™ can be used as a preventative or new-fish quarantine treatment, therapeutic long-term bath, medium bath, or high-dose dip.

Why Choose NitroCure™?

  • 100% pure nitrofurazone with no fillers.
  • Good first-line treatment for many common bacterial infections in koi and goldfish.
  • Well suited for external bacterial issues and pond- or tank-level treatment.
  • Flexible treatment options ranging from a long-term therapeutic bath to short intensive baths and dips.

When NitroCure™ Makes the Most Sense

  • Multiple fish are acting off and you want to treat the system, not just one fish.
  • You are dealing with typical external issues such as ulcers, fin rot, tail rot, or gill irritation.
  • You want a strong starting point before stepping up to a deeper treatment.

If fish are clearly getting worse, not eating, or the infection looks deeper or more advanced, it may be time to step up to a different treatment.

Not sure if this is the right one?

If you are comparing NitroCure, KoiCure, and KanaRx, this quick guide explains when to use each one and why.

Read the guide

Treatment Coverage

One 25 g container of NitroCure™ covers the following approximate water volume depending on the treatment method used:

Treatment Method Dosage Gallons Treated per 25 g Jar
Preventative / New Fish QT
(24 hours) 		25 g / 1,000 gal
(6.6 mg/L) 		≈ 1,000 gallons
Therapeutic Long-Term Bath
(5–7 days) 		37.8 g / 1,000 gal
(10 mg/L) 		≈ 660 gallons
Medium Bath
(3 hours) 		189 g / 1,000 gal
(50 mg/L) 		≈ 132 gallons
High-Dose Dip
(15–20 minutes) 		378–757 g / 1,000 gal
(100–200 mg/L) 		≈ 33–66 gallons

Note: Coverage estimates are based on one 25 g container of NitroCure™. Larger sizes are available for bigger ponds.

  • Aqua Meds NitroCure Instructions

    NitroCure™ Treatment Instructions

    NitroCure™ is 100% pure nitrofurazone. Choose the treatment method that best fits the situation and always monitor fish closely during treatment.

    Conversion: 3.78 g per 1,000 gallons = 1 mg/L.

    1. Preventative / New Fish QT Treatment

    Purpose: Quarantine or preventative treatment for new fish.
    Duration: 24 hours.

    Dosage: 25 g per 1,000 gallons (6.6 mg/L).
    Examples: 250 gallons → 6.25 g | 500 gallons → 12.5 g | 1,000 gallons → 25 g

    1. Pre-dissolve the measured NitroCure in pond water.
    2. Add the solution to an isolated quarantine or treatment tank.
    3. Maintain strong aeration throughout treatment.
    4. Leave the fish in the treated water for 24 hours.
    5. Replace 70–100% of the treatment water after 24 hours.
    6. If additional treatment is needed, repeat the full dose daily for up to 3 days.
    7. Observe fish closely and discontinue treatment if excessive stress is observed.

    2. Therapeutic Long-Term Bath

    Purpose: Extended antibacterial treatment for established bacterial infections.
    Duration: 5–7 days.

    Dosage: 37.8 g per 1,000 gallons (10 mg/L).
    Examples: 250 gallons → 9.45 g | 500 gallons → 18.9 g | 1,000 gallons → 37.8 g

    1. Pre-dissolve the measured NitroCure in pond water.
    2. Add evenly to the treatment system.
    3. Remove activated carbon and other chemical filtration during treatment.
    4. Turn off UV sterilization.
    5. Maintain strong aeration throughout treatment.
    6. Monitor fish and water quality closely during the 5–7 day treatment period.
    7. Discontinue treatment if excessive stress is observed.

    3. Medium Bath — Intensive Treatment

    Purpose: Higher-concentration short-duration treatment for more serious bacterial problems.
    Duration: 3 hours.

    Dosage: 189 g per 1,000 gallons (50 mg/L).
    Examples: 10 gallons → 1.89 g | 25 gallons → 4.73 g | 50 gallons → 9.45 g

    1. Use an isolated treatment tank or container.
    2. Pre-dissolve the measured NitroCure in treatment water.
    3. Provide strong aeration throughout treatment.
    4. Place the fish in the treatment for up to 3 hours.
    5. Observe the fish closely throughout the entire treatment.
    6. Remove the fish immediately if excessive stress is observed.
    7. Return the fish to clean, well-aerated water after treatment.

    4. High-Dose Dip — Intensive Treatment

    Purpose: Short, high-concentration exposure for severe localized bacterial infections.
    Duration: 15–20 minutes.

    Dosage: 378–757 g per 1,000 gallons (100–200 mg/L), which is approximately 0.38–0.76 g per gallon.
    Example: 5 gallons → approximately 1.9–3.8 g

    1. Use a clean, isolated treatment container.
    2. Fill with fresh, dechlorinated pond water.
    3. Pre-dissolve the measured NitroCure before adding the fish.
    4. Provide strong aeration.
    5. Place the fish in the dip for 15–20 minutes while observing continuously.
    6. Remove the fish immediately if excessive stress is observed.
    7. Return the fish to clean, well-aerated pond or recovery water after treatment.

    Quick Reference Dosage Table

    Treatment Dosage Duration
    Preventative / New Fish QT 25 g / 1,000 gal
    (6.6 mg/L)    		 24 hours
    Repeat daily up to 3 days after 70–100% water replacement
    Therapeutic Long-Term Bath 37.8 g / 1,000 gal
    (10 mg/L)    		 5–7 days
    Medium Bath 189 g / 1,000 gal
    (50 mg/L)    		 3 hours
    High-Dose Dip 378–757 g / 1,000 gal
    (100–200 mg/L)    		 15–20 minutes

    Temperature Note

    NitroCure™ is most effective at water temperatures of 60°F (15.5°C) or above. Performance decreases in colder water.

    Important Treatment Notes

    • Pre-dissolve NitroCure™ in pond or treatment water before use.
    • Use an isolated treatment tank whenever practical.
    • Maintain strong aeration throughout treatment.
    • Turn off UV sterilization during treatment.
    • Remove activated carbon and other chemical filtration during treatment.
    • Observe fish closely and discontinue treatment if excessive stress is observed.
  • Aqua Meds NitroCure Precautions

    Precautions & Safety Information

    • Keep Out of Reach of Children and Pets: Store NitroCure™ in a secure location.
    • For Ornamental Fish Only: Not for use on fish intended for human consumption.
    • Protective Gear: Wear gloves when handling NitroCure™ and avoid skin and eye contact. Wash hands thoroughly after use.
    • Storage: Store in a cool, dry place with the container tightly sealed. Protect from moisture.
    • Filtration: Remove activated carbon and other chemical filtration during treatment because they may remove the medication from the water.
    • Water Quality: Maintain strong aeration and monitor water quality during treatment, including ammonia and nitrite.
    • Avoid Overdosing: Measure NitroCure™ carefully and follow the recommended dosage and treatment duration.
    • Observe Fish Closely: Discontinue treatment if excessive stress is observed.

    NitroCure™ is intended for ornamental koi and goldfish only. Always follow the treatment directions carefully.

  • Choosing Between NitroCure™, KoiCure™, and KanaRx™

    Q: How do NitroCure™, KoiCure™, and KanaRx™ differ?
    A: All three are pure Aqua Meds antibiotic treatments, but each is best suited to different situations and treatment methods.

    • NitroCure™ (nitrofurazone) – Primarily a waterborne treatment for external bacterial problems such as ulcers, fin rot, tail rot, mouth rot, and bacterial gill disease. NitroCure™ is especially useful when multiple fish are affected or when treating the pond, quarantine tank, or treatment system makes more sense than treating individual fish. It can be used as a preventative/new-fish quarantine treatment, therapeutic long-term bath, medium bath, or high-dose dip.
    • KoiCure™ (oxolinic acid) – A versatile antibiotic that can be used as an immersion treatment or in medicated food. KoiCure™ is especially useful when bacterial infections are persistent, when redness or ulceration suggests a more established infection, or when the fish are still eating well and medicated food provides a practical way to treat systemically.
    • KanaRx™ (kanamycin sulfate) – A strong broad-spectrum antibiotic used as an immersion or therapeutic bath treatment for serious bacterial infections. KanaRx™ can be a good option when another antibiotic has not produced the desired response or when the suspected bacteria may respond better to kanamycin.

    Do not use NitroCure™, KoiCure™, and KanaRx™ at full strength at the same time. Using multiple antibiotics together does not automatically make treatment more effective and can add unnecessary stress to the fish and biological filtration.

    When possible, choose the antibiotic and treatment method that best fit the symptoms, number of fish affected, severity of the problem, and whether the fish are still eating. If one treatment clearly works, there is usually no reason to change antibiotics simply for the sake of using something different.

    Q: Which one should I use?
    A: As a practical starting point:

    • If several fish have primarily external bacterial problems and you want to treat the water, NitroCure™ is often a good first choice.
    • If the fish are still eating well and you want to treat through medicated food, or if the infection is persistent or more established, KoiCure™ is often the better choice.
    • If you are dealing with a serious bacterial infection or the fish have not responded as expected to another antibiotic, KanaRx™ may be the better treatment.

    For significant ulcers or localized wounds, topical treatment can also be used along with the appropriate antibiotic treatment.

    For a more detailed comparison and dosing overview, read our full guide:
    NitroCure™ vs. KoiCure™ vs. KanaRx™: Which Aqua Meds Antibiotic Should I Use?

  • Is this the right Aqua Meds® product for my sick fish or pond water problem?
  • Aqua Meds Dealers

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